Assaying blood cell populations of the Drosophila melanogaster larva. Dev Cell. In adult Drosophila, the biggest reservoir of hemocytes surrounds the extensive respiratory epithelia (tracheal air sacs) of the thorax and head (Sanchez Bosch et al. Since joining the faculty of UCSF in late 2006, Katja has received a Hellman Family Scholar Award, an American Cancer Society Research Scholar Award, an American Heart Association career development award, and she is funded by research grants from the National Science Foundation and the National Institutes of Health. Adult Drosophila Lack Hematopoiesis but Rely on a Blood Cell Reservoir at the Respiratory Epithelia to Relay Infection Signals to Surrounding Tissues. Regulation of Drosophila hematopoietic sites by Activin-ß from active sensory neurons. 2016 Mar 07; 26(5):575-84. Derived automatically from this person's publications.

Exp Hematol. 1998 Jun; 8(3):375-82. Brückner K, Pasquale EB, Klein R. PMID: 9054357. (3) Signaling mechanisms of epithelial-mesenchymal transition The PDGF/VEGF receptor controls blood cell survival in Drosophila.

Labrador JP, Azcoitia V, Tuckermann J, Lin C, Olaso E, Mañes S, Brückner K, Goergen JL, Lemke G, Yancopoulos G, Angel P, Martínez C, Klein R. PMID: 11375938. Since joining the faculty of UCSF in late 2006, Katja has received a Hellman Family Scholar Award, an American Cancer Society Research Scholar Award, an American Heart Association career development award, and she is funded by research grants from the National Science Foundation and the National Institutes of Health. However, the cell biological effects and cooperating signaling pathways of BMP-induced EMT are still under scrutiny. The PDGF/VEGF receptor controls blood cell survival in Drosophila. Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications. 2015 Mar; 11(3):e1005056. We investigate this question using a dual Drosophila model consisting of complementary cell-based and in vivo systems. PLoS Genet. 1996; 8(2-3):199-209. 2011 Dec; 138(24):5379-91. This graph shows the total number of publications by year. She performed her postdoctoral studies at the EMBL and Harvard Medical School. Adult Drosophila Lack Hematopoiesis but Rely on a Blood Cell Reservoir at the Respiratory Epithelia to Relay Infection Signals to Surrounding Tissues. Signaling by Eph receptors and their ephrin ligands. 1999 Mar; 22(3):511-24. Current research focuses on mechanisms of blood cell transdifferentiation, dissecting the role of specific sensory neurons and their environmental activation in this process (Corcoran et al. We further examine the contribution of other neuron-produced factors on blood cell development and pathologies. Makhijani K, Alexander B, Tanaka T, Rulifson E, Brückner K. PMID: 22071105. Mol Cell Neurosci. Brückner K, Kockel L, Duchek P, Luque CM, Rørth P, Perrimon N. PMID: 15239955. Science.

J Cell Sci. Extracellular Reactive Oxygen Species Drive Apoptosis-Induced Proliferation via Drosophila Macrophages. She performed her postdoctoral studies at the EMBL and Harvard Medical School. Fly 2012; Gold and Brückner, Seminars in Immunology 2015; Makhijani et al. 2000 Jul 27; 406(6794):411-5. Regulation of Drosophila hematopoietic sites by Activin-ß from active sensory neurons. EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains. The principal role of the adult blood cell system is to relay the trigger of bacterial infection to a humoral immune response in the respiratory epithelia and fat body (Sanchez Bosch et al. 2013 Jul 11; 51(1):5-19. Translational Sciences (Grant Number UL1 TR000004) at the National Institutes of Health (NIH). BMP-induced EMT drives organ development and tumor metastasis, e.g.

Katja was a Howard Hughes Medical Institute Associate, long-term post-doctoral fellow of the European Molecular Biology Organization (EMBO) and Human Frontier Science Program (HFSP), and Special Fellow of the Leukemia & Lymphoma Society (LLS). We further examine the contribution of other neuron-produced factors on blood cell development and pathologies. Glycosyltransferase activity of Fringe modulates Notch-Delta interactions. in biology and cell signalling from the European Molecular Biology Laboratory (EMBL) and the University of Heidelberg, Germany. Note that an individual publication can be assigned to more than one field. Curr Opin Neurobiol. Katrina joined the Brückner lab in May 2014, extending her expertise in neuro- and stem cell biology to the neuronal regulation of blood cells. She performed her postdoctoral studies at the EMBL and Harvard Medical School. She performed her postdoctoral studies at the EMBL and Harvard Medical School. . Doch der Kennenlern-Nachmittag … (3) Signaling mechanisms of epithelial-mesenchymal transition bioRxiv 2020). We study this question of inter-organ/-tissue communication in immunity using a simple Drosophila model. She performed her postdoctoral studies at the EMBL and Harvard Medical School. This graph shows the number and percent of publications by field. Journal of Visualized Experiments (JoVE). Renal Function: Guardian of Immune Homeostasis. 2015; (In press). Makhijani K, Alexander B, Rao D, Petraki S, Herboso L, Kukar K, Batool I, Wachner S, Gold KS, Wong C, O'Connor MB, Brückner K. PMID: 28748922. bioRxiv 2020). She performed her postdoctoral studies at the EMBL and Harvard Medical School. Curr Biol. in biology and cell signalling from the European Molecular Biology Laboratory (EMBL) and the University of Heidelberg, Germany. part of the Clinical and Translational Science Award program funded by the National Center for Advancing Mol Cell.

Arginine Methylation Initiates BMP-Induced Smad Signaling. Nature Communications 2017). Of blood cells and the nervous system: hematopoiesis in the Drosophila larva. The Brückner lab addresses fundamental questions in development, homeostasis, and malignant disease, studying paradigms in the invertebrate genetic model organism Drosophila melanogaster. Development 2011; Makhijani et al. We address this question using a simple model of hematopoietic sites (hematopoietic pockets) in the Drosophila larva (Makhijani et al. The collagen receptor DDR2 regulates proliferation and its elimination leads to dwarfism. We dissect mechanisms of this relay including the coordination of multiple signaling pathways and signaling in multiple tissues. Tyrosine phosphorylation of transmembrane ligands for Eph receptors. Neuron. Sanchez Bosch P, Makhijani K, Herboso L, Gold KS, Baginsky R, Woodcock KJ, Alexander B, Kukar K, Corcoran S, Jacobs T, Ouyang D, Wong C, Ramond EJV, Rhiner C, Moreno E, Lemaitre B, Geissmann F, Brückner K. PMID: 31735669. Researchers can. Current research focuses on cell signaling, the role of the microenvironment, hematopoiesis, innate immunity, epithelial-mesenchymal transition, and organ development. Katja Brueckner received her PhD. Similarities and differences in the way transmembrane-type ligands interact with the Elk subclass of Eph receptors. Since joining the faculty of UCSF in late 2006, Katja has received a Hellman Family Scholar Award, an American Cancer Society Research Scholar Award, an American Heart Association career development award, and she is funded by research grants from the National Science Foundation and the National Institutes of Health. Katja Brueckner received her PhD. Associate Professor, Cell and Tissue Biology, Program for Breakthrough Biomedical Research (PBBR). in pancreatic cancer. Katja Brückner (Julia Jäger) und Roland Heilmann (Thomas Rühmann) haben beschlossen, ihre Beziehung offiziell zu machen. 2012 Mar 15; 125(Pt 6):1393-400. However, the cell biological effects and cooperating signaling pathways of BMP-induced EMT are still under scrutiny. Copyright © The Regents of the University of California. expression of antimicrobial peptides (AMPs)) to protect the organism from infection and other pathological conditions. While core signaling pathways of the NFkB family and Jak/Stat signaling are well established in this context, it is far less understood how multiple organs and tissues communicate with each other to elicit powerful local humoral immune responses. Katja Brueckner received her PhD. Dev Cell 2019). PLoS Genet. For her post-doctoral studies, the LLS awarded Katja with the Brian P. ODell Memorial Research Award. Katja was a Howard Hughes Medical Institute Associate, long-term post-doctoral fellow of the European Molecular Biology Organization (EMBO) and Human Frontier Science Program (HFSP), and Special Fellow of the Leukemia & Lymphoma Society (LLS). Kockel L, Kerr KS, Melnick M, Brückner K, Hebrok M, Perrimon N. PMID: 20585550. A poorly understood group of EMT inducers are Bone Morphogenetic Proteins (BMPs), secreted ligands of the TGF-ß family. Innate immunity relies on humoral responses (e.g. 2019 12 16; 51(6):787-803.e5. Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. 2012 Oct-Dec; 6(4):254-60. Dev Cell 2019). Renal Function: Guardian of Immune Homeostasis. Development 2011), and hemocyte proliferation is promoted by Activin-b produced by active sensory neurons (Makhijani et al. We dissect mechanisms of this relay including the coordination of multiple signaling pathways and signaling in multiple tissues. The principal role of the adult blood cell system is to relay the trigger of bacterial infection to a humoral immune response in the respiratory epithelia and fat body (Sanchez Bosch et al. in biology and cell signalling from the European Molecular Biology Laboratory (EMBL) and the University of Heidelberg, Germany. UCSF Profiles is managed by the UCSF Dev Cell 2019). While core signaling pathways of the NFkB family and Jak/Stat signaling are well established in this context, it is far less understood how multiple organs and tissues communicate with each other to elicit powerful local humoral immune responses. BMP-induced EMT drives organ development and tumor metastasis, e.g. Makhijani K, Brückner K. PMID: 23022764. Sanchez Bosch P, Makhijani K, Herboso L, Gold KS, Baginsky R, Woodcock KJ, Alexander B, Kukar K, Corcoran S, Jacobs T, Ouyang D, Wong C, Ramond EJV, Rhiner C, Moreno E, Lemaitre B, Geissmann F, Brückner K, Makhijani K, Alexander B, Rao D, Petraki S, Herboso L, Kukar K, Batool I, Wachner S, Gold KS, Wong C, O'Connor MB, Brückner K, Fogarty CE, Diwanji N, Lindblad JL, Tare M, Amcheslavsky A, Makhijani K, Brückner K, Fan Y, Bergmann A, Sopko R, Lin YB, Makhijani K, Alexander B, Perrimon N, Brückner K. Petraki, S., Alexander, B., Brückner, K.. Xu J, Wang AH, Oses-Prieto J, Makhijani K, Katsuno Y, Pei M, Yan L, Zheng YG, Burlingame A, Brückner K, Derynck R, Makhijani K, Alexander B, Tanaka T, Rulifson E, Brückner K, Kockel L, Kerr KS, Melnick M, Brückner K, Hebrok M, Perrimon N, Brückner K, Kockel L, Duchek P, Luque CM, Rørth P, Perrimon N, Labrador JP, Azcoitia V, Tuckermann J, Lin C, Olaso E, Mañes S, Brückner K, Goergen JL, Lemke G, Yancopoulos G, Angel P, Martínez C, Klein R, Brückner K, Pablo Labrador J, Scheiffele P, Herb A, Seeburg PH, Klein R, Brambilla R, Brückner K, Orioli D, Bergemann AD, Flanagan JG, Klein R, ©2020 The Regents of the University of California, DSCB 257 Developmental & Stem Cell Biology.

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